In this passage, it is more likely that Jesus speaks of gaining entrance into the Kingdom of God rather than being born-again,
as the verse is sandwiched between two descriptions of the Kingdom of God. Just prior to that, Jesus said, "To what shall I compare the Kingdom of God?" And he goes on to describe a bread-making process using an example of fermentation.
He says of the Kingdom of God, "It is to ferment, which a woman getting, hides in three measures of meal till the whole was fermented."
The Kingdom of God has three phases, two of them include a fermenting process. In the final phase, the fermenting process will be completed.
The Kingdom that exists, as this is being written, is through the indwelling presence of the Holy Spirit within all believers. The Bible says, The Kingdom of God is within you. But this is just phase one of the Kingdom. In phase two, we look forward to a physical, global Kingdom.
In phase two, Jesus, the Son of David, at his return, defeats his enemies at the Battle of Armageddon and sits upon the Throne of David to pass judgement over what is left of humanity after the Time of Jacob's Trouble is concluded. Jacob's Trouble is also known as "a Time of Trouble" and corresponds with what many Christians know as the "Great Tribulation." Jesus spoke of this in Matthew 24, and corresponded it with something called the abomination of desolation that would be set up in the Holy of Holies, in Jerusalem.
But there's more! Next, comes phase three, where the fermenting process is completed. The old is passed away, and all things become new. The Eternal Kingdom of God will continue forever in the New Heavens and the New Earth.
The rest of this commentary will focus primarily on the phase two.
Jesus preached the Kingdom of God, and had much to say about the times immediately preceding and following the Time of Jacob's Trouble...and his triumphant and visible return at the Battle of Armageddon.
He went through the cities and villages teaching and journeying towards Jerusalem. As he went, someone asked, "Lord, are there few that be saved?"
Jesus answered and said, "When once the home-owner is roused up from locking the door because you begin to stand outside and to knock at the door saying Lord Lord open unto us He shall answer and say to you I am not acquainted with you from where you are [from]. Then shall you begin to say We have eaten and drunk in your presence and you have taught in our streets. But he shall be declaring, I tell you I am not acquainted [with] you [or] where you are from! Depart from me! Every one of you! Workers of iniquity!
His answer reveals that, in this discourse, our Savior is speaking to those who survive the Great Tribulation [the Time of Jacob's Trouble] but will not be granted entrance into the Kingdom of God. At the Judgement of the Nations, those on the right hand of the King, are told this Kingdom has been prepared for those on the right, who are called the "Sheep." And it has been prepared from the foundation of the world. The Judgement of the Nations will take place on earth after Jesus returns in power and great glory.
He said on that day, "There shall be weeping and gnashing of teeth when you shall see Abraham and Isaac and Jacob and all the prophets in the Kingdom of God and you yourselves thrust out. And they shall come from the east and from the west and from the north and from the south and shall sit down in the Kingdom of God."
This last is nothing else but a description of the Marriage Supper of the Lamb and his Bride.
Jesus continues saying, "And behold there are last which shall be first and there are first which shall be last." I believe this may be a reference to the seating order at the Wedding Feast, which will also take place on earth, after Christ's return with his Bride, the Lamb's wife...Just some food for thought.
Are we looking up? Our redemption draws near.
Right now, the invitation to attend the wedding as the Bride, is still open. Accept that invitation, continue in the faith, and we have assurance that we will never hear those dreadful words applied to us. Accept the invitation, and we need not fear being counted among those who will hear "Depart from me you worker of iniquity! I was never acquainted with you, or with where you are from!"